Reciprocal interactions between epithelium and mesenchyme mediate crucial aspects of
embryonic development and direct the coordinated organogenesis, correct spatial …

The pathogenesis of pulmonary fibrosis remains incompletely understood. Studies of
associated inflammation have led to the discovery of a number of cytokines and chemokines …

There are currently few treatment options for pulmonary fibrosis. Innovations may come from
a better understanding of the cellular origin of the characteristic fibrotic lesions. We have …

Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and
biochemical features of smooth muscle (SM) cells, including the presence of microfilament …

Appearance of contractile filament-laden stromal cells or myofibroblasts is a characteristic of
lung fibrotic lesions. The role of these cells in fibrosis and their cytoskeletal phenotype are …

Tumors arise from cells that have sustained genetic mutations resulting in deregulation of
several of their normal growth-controlling mechanisms. Much of the research concerning the …

The synthesis of collagen and EIIIA-containing cellular fibronectin in certain forms of
pulmonary fibrosis occurs in discrete locations: in the Masson bodies in bronchiolitis …

The origin of myofibroblasts in stromal reaction has been a subject of controversy. To
address this question definitively, we developed techniques for purification and …

Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts
(iReFs) to direct the behavior of the epithelial stem cell niche. During lung development …

Fibroblast differentiation to the myofibroblast phenotype is associated with α–smooth-muscle
actin (α-SMA) expression and regulated by cytokines. Among these, transforming growth …