Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Envelope biogenesis and homeostasis in gram-negative bacteria are exceptionally intricate
processes that require a multitude of periplasmic chaperones to ensure cellular survival …

Interbacterial antagonism and associated defensive strategies are both essential during
bacterial competition. The human gut symbiont Bacteroides fragilis secretes a ubiquitin …

Single-molecule FRET (smFRET) has become a mainstream technique for studying
biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by …

The outer membrane is a formidable barrier that protects Gram-negative bacteria against
environmental threats. Its integrity requires the correct folding and insertion of outer …

Chemical crosslinking‐mass spectrometry (XL‐MS) is a valuable technique for gaining
insights into protein structure and the organization of macromolecular complexes. XL‐MS …

The folding of proteins into their native structure is crucial for the functioning of all biological
processes. Molecular chaperones are guardians of the proteome that assist in protein …

To reach their final destinations, outer membrane proteins (OMPs) of gram-negative bacteria
undertake an eventful journey beginning in the cytosol. Multiple molecular machines …

The emergence of ultra-large screening libraries, filled to the brim with billions of readily
available compounds, poses a growing challenge for docking-based virtual screening …

Correct folding of outer membrane proteins (OMPs) into the outer membrane of Gram-
negative bacteria depends on delivery of unfolded OMPs to the β-barrel assembly …