Ascorbic acid: much more than just an antioxidant

O Arrigoni, MC De Tullio - Biochimica et Biophysica Acta (BBA)-General …, 2002 - Elsevier
Vitamin C (ascorbic acid (AA)) is very popular for its antioxidant properties. Consequently,
many other important aspects of this multifaceted molecule are often underestimated or even …

Ascorbate as seen through plant evolution: the rise of a successful molecule?

N Gest, H Gautier, R Stevens - Journal of Experimental Botany, 2013 - academic.oup.com
Ascorbate is a widespread and efficient antioxidant that has multiple functions in plants,
traditionally associated with the reactions of photosynthesis. This review aims to look at …

The antioxidant systems vis-à-vis reactive oxygen species during plant–pathogen interaction

L De Gara, MC de Pinto, F Tommasi - Plant Physiology and Biochemistry, 2003 - Elsevier
Plant resistance to pathogens requires the activation of complex metabolic pathways in the
infected cells, aimed at recognizing pathogen presence and hindering its propagation within …

Metal/metalloid stress tolerance in plants: role of ascorbate, its redox couple, and associated enzymes

NA Anjum, SS Gill, R Gill, M Hasanuzzaman… - Protoplasma, 2014 - Springer
The enhanced generation of reactive oxygen species (ROS) under metal/metalloid stress is
most common in plants, and the elevated ROS must be successfully metabolized in order to …

Modulation of redox homeostasis: A strategy to overcome cancer drug resistance

Y Li, X Zhang, Z Wang, B Li, H Zhu - Frontiers in Pharmacology, 2023 - frontiersin.org
Cancer treatment is hampered by resistance to conventional therapeutic strategies,
including chemotherapy, immunotherapy, and targeted therapy. Redox homeostasis …

Vitamin C is a kinase inhibitor: dehydroascorbic acid inhibits IκBα kinase β

JM Cárcamo, A Pedraza, O Bórquez-Ojeda… - … and cellular biology, 2004 - Taylor & Francis
Reactive oxygen species (ROS) are key intermediates in cellular signal transduction
pathways whose function may be counterbalanced by antioxidants. Acting as an antioxidant …

A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid

MA Castro, FA Beltrán, S Brauchi… - Journal of …, 2009 - Wiley Online Library
In this review, we discuss a novel function of ascorbic acid in brain energetics. It has been
proposed that during glutamatergic synaptic activity neurons preferably consume lactate …

Antiviral effects of ascorbic and dehydroascorbic acids in vitro

A Furuya, M Uozaki, H Yamasaki… - International …, 2008 - spandidos-publications.com
In the present study, ascorbic acid weakly inhibited the multiplication of viruses of three
different families: herpes simplex virus type 1 (HSV-1), influenza virus type A and poliovirus …

The ascorbic acid system in seeds: to protect and to serve

MC De Tullio, O Arrigoni - Seed Science Research, 2003 - cambridge.org
The ascorbic acid (ASC) system functions dynamically in seeds, although the strategies for
ASC production and utilization may vary according to seed developmental and functional …

Adverse effects of antioxidative vitamins

M Rutkowski, K Grzegorczyk - International journal of occupational …, 2012 - Springer
High doses of synthetic antioxidative vitamins: A, E, C and β-carotene are often used on long-
term basis in numerous preventive and therapeutic medical applications. Instead of …