Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

Over the past decade, immune-checkpoint inhibitors (ICIs) have revolutionized the treatment
of cancer. In mesothelioma, a rare cancer with a dismal prognosis generally caused by …

Purpose: Adoptive T-cell immunotherapy with tumor infiltrating lymphocytes or genetically-
modified T cells has yielded dramatic results in some cancers. However, T cells need to …

Introduction: B7 homolog 1 (B7-H1; aka programmed cell death 1 ligand 1) is a negative
costimulatory molecule that is associated with poor prognosis in many tumor types. Given …

Malignant pleural mesothelioma (MPM) is a deadly disease that occurs in 2,000 to 3,000
people each year in the United States. Although MPM is an extremely difficult disease to …

Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer that arises from the
mesothelial surface of the pleural and peritoneal cavities, the pericardium, and rarely, the …

Neuroblastoma is a childhood cancer that is fatal in almost half of patients despite intense
multimodality treatment. This cancer is derived from neuroendocrine tissue located in the …

Current cancer treatments may create profound iatrogenic outcomes. The adverse effects of
these treatments still remain, as the serious problems that practicing physicians have to …

Ovarian cancer and malignant mesothelioma frequently express both mesothelin and
CA125 (also known as MUC16) at high levels on the cell surface. The interaction between …

Despite conventional medical and surgical treatments, malignant pleural mesothelioma
(MPM) remains incurable. Oncovirotherapy (ie, the use of replication-competent virus for …