Biochemical and biological attributes of matrix metalloproteinases

N Cui, M Hu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …

Zinc in wound healing modulation

PH Lin, M Sermersheim, H Li, PHU Lee, SM Steinberg… - Nutrients, 2017 - mdpi.com
Wound care is a major healthcare expenditure. Treatment of burns, surgical and trauma
wounds, diabetic lower limb ulcers and skin wounds is a major medical challenge with …

Exploration of the antibacterial and wound healing potential of a PLGA/silk fibroin based electrospun membrane loaded with zinc oxide nanoparticles

K Huang, Z Jinzhong, T Zhu, Y Morsi… - Journal of materials …, 2021 - pubs.rsc.org
Zinc oxide nanoparticles (ZnO NPs) are known for their antibacterial, antioxidant, and anti-
inflammatory activities. Moreover, ZnO NPs can stimulate cell migration, re-epithelialization …

Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures

E Van Goethem, R Poincloux, F Gauffre… - The journal of …, 2010 - journals.aai.org
Tissue infiltration of macrophages, although critical for innate immunity, is also involved in
pathologies, such as chronic inflammation and cancer. In vivo, macrophages migrate mostly …

Matrix metalloproteinases in kidney homeostasis and diseases

RJ Tan, Y Liu - American journal of physiology-renal …, 2012 - journals.physiology.org
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have
been increasingly linked to both normal physiology and abnormal pathology in the kidney …

Intricate functions of matrix metalloproteinases in physiological and pathological conditions

R Mittal, AP Patel, LH Debs, D Nguyen… - Journal of cellular …, 2016 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a diverse group of proteolytic enzymes and play an
important role in the degradation and remodeling of the extracellular matrix (ECM). In normal …

Matrix-metalloproteinases as targets for controlled delivery in cancer: An analysis of upregulation and expression

KJ Isaacson, MM Jensen, NB Subrahmanyam… - Journal of Controlled …, 2017 - Elsevier
While commonly known for degradation of the extracellular matrix, matrix metalloproteinases
(MMPs) exhibit broad potential for use in targeting of bioactive and imaging agents in cancer …

Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products

V Garceau, J Smith, IR Paton, M Davey… - Journal of leukocyte …, 2010 - academic.oup.com
These studies demonstrate that CSF-1 and IL-34 are conserved in birds, and uses
evolutionary comparisons to infer structure function relationships among vertebrate animals …

Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway

D Blackiston, DS Adams, JM Lemire… - Disease models & …, 2011 - journals.biologists.com
Understanding the mechanisms that coordinate stem cell behavior within the host is a high
priority for developmental biology, regenerative medicine and oncology. Endogenous ion …

NF-κB signaling in fetal lung macrophages disrupts airway morphogenesis

TS Blackwell, AN Hipps, Y Yamamoto… - The Journal of …, 2011 - journals.aai.org
Bronchopulmonary dysplasia is a common pulmonary complication of extreme prematurity.
Arrested lung development leads to bronchopulmonary dysplasia, but the molecular …