Obesity as a risk factor for dementia and Alzheimer's disease: the role of leptin

JA Flores-Cordero, A Pérez-Pérez… - International journal of …, 2022 - mdpi.com
Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …

[HTML][HTML] Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review

J Chu, S Feng, C Guo, B Xue, K He, L Li - Biomedicine & …, 2023 - Elsevier
The gut microbiota is indispensable for maintaining host health by enhancing the host's
digestive capacity, safeguarding the intestinal epithelial barrier, and preventing pathogen …

[HTML][HTML] Exploring the links between obesity and psoriasis: a comprehensive review

G Barros, P Duran, I Vera, V Bermúdez - International Journal of …, 2022 - mdpi.com
Obesity is a major public health issue worldwide since it is associated with the development
of chronic comorbidities such as type 2 diabetes, dyslipidemias, atherosclerosis, some …

Gut microbiota metabolites in major depressive disorder—Deep insights into their pathophysiological role and potential translational applications

MA Ortega, MA Alvarez-Mon, C García-Montero… - Metabolites, 2022 - mdpi.com
The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning
of the organism, affecting the health and disease status of the individuals. There is …

[HTML][HTML] Deciphering the gut microbiome in neurodegenerative diseases and metagenomic approaches for characterization of gut microbes

N Singh, V Singh, SN Rai, V Mishra, E Vamanu… - Biomedicine & …, 2022 - Elsevier
The central nervous system has essential role in the regulation of the physiological condition
of the human body. Gut microbes cause several types of gastrointestinal diseases like ulcer …

What are the key gut microbiota involved in neurological diseases? A systematic review

B Bonnechère, N Amin, C van Duijn - International Journal of Molecular …, 2022 - mdpi.com
There is a growing body of evidence highlighting there are significant changes in the gut
microbiota composition and relative abundance in various neurological disorders. We …

Adipose tissue, systematic inflammation, and neurodegenerative diseases

APA Boleti, PHO Cardoso, BEF Frihling… - Neural Regeneration …, 2023 - journals.lww.com
Obesity is associated with several diseases, including mental health. Adipose tissue is
distributed around the internal organs, acting in the regulation of metabolism by storing and …

The blood–brain barrier, oxidative stress, and insulin resistance

WA Banks, EM Rhea - Antioxidants, 2021 - mdpi.com
The blood–brain barrier (BBB) is a network of specialized endothelial cells that regulates
substrate entry into the central nervous system (CNS). Acting as the interface between the …

[HTML][HTML] Association between Parkinson's disease and diabetes mellitus: From epidemiology, pathophysiology and prevention to treatment

H Yu, T Sun, X He, Z Wang, K Zhao, J An, L Wen… - Aging and …, 2022 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) and Parkinson's disease (PD) are both age-related diseases of
global concern being among the most common chronic metabolic and neurodegenerative …

[HTML][HTML] The effect of curcumin supplementation on weight loss and anthropometric indices: An umbrella review and updated meta-analyses of randomized controlled …

C Unhapipatpong, N Polruang… - The American Journal of …, 2023 - Elsevier
Background Curcumin supplementation may promote weight loss and ameliorate obesity-
related complications through its antioxidative and anti-inflammatory properties. Objective …