Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection

D Martin, R Tarleton - Immunological reviews, 2004 - Wiley Online Library
CD8+ T cells are crucial to the control of Trypanosoma cruzi infection and probably act via
multiple mechanisms, the most important being the production of interferon‐γ (IFN‐γ). In the …

Frequency of Interferon-γ-Producing T Cells Specific for Trypanosoma cruzi Inversely Correlates with Disease Severity in Chronic Human Chagas Disease

SA Laucella, M Postan, D Martin… - Journal of Infectious …, 2004 - academic.oup.com
This study sought to quantify CD8+ T cell responses to Trypanosoma cruzi and to identify
potential links between these responses and the severity of disease in humans. In the …

Anin SituQuantitative Immunohistochemical Study of Cytokines and IL-2R+ in Chronic Human Chagasic Myocarditis: Correlation with the Presence of …

MM Reis, M de Lourdes Higuchi, LA Benvenuti… - Clinical Immunology and …, 1997 - Elsevier
Inflammatory cells positive for the cytokines IL-2, IL-4, IL-6, TNF-α, and IFN-γ and for IL-2R,
as well as CD8+ and CD4+ T cells and B cells were quantified using an immunoperoxidase …

Association of an increase in CD8+ T cells with the presence of Trypanosoma cruzi antigens in chronic, human, chagasic myocarditis.

MD Higuchi, MM Ries, VD Aiello… - The American journal …, 1997 - europepmc.org
The role of Trypanosoma cruzi in the pathogenesis of myocarditis in the chronic phase of
Chagas' disease is still controversial, with autoimmune mechanisms frequently being …

“Autoimmune rejection” of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue

RL Tarleton, L Zhang… - Proceedings of the …, 1997 - National Acad Sciences
Infection with the protozoan parasite Trypanosoma cruzi often results in chronic heart-and
gut-associated disease known as Chagas disease. In this study we show that contrary to …

[HTML][HTML] Prevalence of CD8+ αβ T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62LLowLFA-1HighVLA-4High activation …

PVA dos Santos, E Roffê, HC Santiago, RA Torres… - Microbes and …, 2001 - Elsevier
The determinants of the prevalence of CD8+ T cells in the inflamed myocardium of
Trypanosoma cruzi-infected patients and experimental animals are undefined. Using …

[HTML][HTML] Absence of seasonal effect on the immunomodulatory action of Brazilian propolis on natural killer activity

JM Sforcin, R Kaneno, SRC Funari - Journal of Venomous Animals …, 2002 - SciELO Brasil
Propolis, a beehive product widely used in folk medicine as an antiinflammatory agent, has
been attracting researchers' attention to scientifically elucidate its biological properties and …

Amastigote surface proteins of Trypanosoma cruzi are targets for CD8+ CTL

HP Low, MAM Santos, B Wizel… - The Journal of …, 1998 - journals.aai.org
Amastigotes of Trypanosoma cruzi express surface proteins that, when released into the
host cell cytoplasm, are processed and presented on the surface of infected cells in the …

Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice

R Kaneno, LM Fontanari, SA Santos, LC Di Stasi… - Food and Chemical …, 2004 - Elsevier
Agaricus blazei Murrill, is an edible and medicinal mushroom which is popularly consumed
due to its antitumoral properties. The immunomodulatory effects of methanol (METH) …

Vaccination with Trypomastigote Surface Antigen 1-Encoding Plasmid DNA Confers Protection against Lethal Trypanosoma cruzi Infection

B Wizel, N Garg, RL Tarleton - Infection and immunity, 1998 - Am Soc Microbiol
ABSTRACT DNA vaccination was evaluated with the experimental murine model of
Trypanosoma cruzi infection as a means to induce antiparasite protective immunity, and the …