Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

With more than 795,000 cases occurring every year, stroke has become a major problem in
the United States across all demographics. Stroke is the leading cause of long-term …

Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Excessive mitochondrial fission is a prominent early event and contributes to mitochondrial
dysfunction, synaptic failure, and neuronal cell death in the progression of Alzheimer's …

Ischemic stroke is related to a variety of physiological and pathological processes including
autophagy and apoptosis. Growth arrest-specific 5 (GAS5), a long non-coding RNA …

Ischemic stroke is a leading cause of morbidity and death, with the outcome largely
determined by the amount of hypoxia-related neuronal death in the affected brain regions …

The Notch signaling pathway is an evolutionarily conserved pathway that modulates normal
biological processes involved in cellular differentiation, apoptosis, and stem cell self …

Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles
in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the …

Introduction Intermittent fasting (IF) has been suggested to have neuroprotective effects
through the activation of multiple signaling pathways. Rodents fasted intermittently exhibit …