Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

E Plazas, DR Muñoz - Pharmacological Research, 2022 - Elsevier
Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …

Huperzine A and its neuroprotective molecular signaling in Alzheimer's disease

MJ Friedli, NC Inestrosa - Molecules, 2021 - mdpi.com
Huperzine A (HupA), an alkaloid found in the club moss Huperzia serrata, has been used for
centuries in Chinese folk medicine to treat dementia. The effects of this alkaloid have been …

Potential therapeutic use of plant flavonoids in AD and PD

S Meng-Zhen, L Ju, Z Lan-Chun, D Cai-Feng… - Heliyon, 2022 - cell.com
Background Millions of people suffer from Alzheimer's disease (AD) and Parkinson's
disease (PD) worldwide. Due to their complex pathology, no effective pharmacological …

Genus Rauvolfia: A review of its ethnopharmacology, phytochemistry, quality control/quality assurance, pharmacological activities and clinical evidence

S Kumar, D Kumari, B Singh - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance The plants are from the genus Rauvolfia Plum. ex
L.(Apocynaceae), which is represented by 74 species with many synonyms, and distributed …

Natural alkaloids as multi-target compounds towards factors implicated in Alzheimer's disease

R Vrabec, G Blunden, L Cahlíková - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …

Plant terpenoids as the promising source of cholinesterase inhibitors for anti-AD therapy

S Lai Shi Min, SY Liew, NJY Chear, BH Goh, WN Tan… - Biology, 2022 - mdpi.com
Simple Summary Plant-derived terpenes have been a research interest in the recent years,
as they are believed to possess the ability to function as a cholinesterase inhibitor. As the …

Exploration of isoquinoline alkaloids as potential inhibitors against human islet amyloid polypeptide

Y Wang, T Zheng, Y Huo, W Du - ACS Chemical Neuroscience, 2022 - ACS Publications
Type-2 diabetes mellitus (T2DM) is one of the most concerning public health problems
because of its high incidence, multiple complications, and difficult treatment. Human islet …

Huperzine—A improved animal behavior in cuprizone-induced mouse model by alleviating demyelination and neuroinflammation

H Zhang, D Wang, J Sun, Y Wang, S Wu… - International Journal of …, 2022 - mdpi.com
Huperzine A (HupA) is a natural acetylcholinesterase inhibitor (AChEI) with the advantages
of high efficiency, selectivity as well as reversibility and can exhibit significant therapeutic …

Research progress on neuroprotective effects of isoquinoline alkaloids

J Li, Y Wu, S Dong, Y Yu, Y Wu, B Xiang, Q Li - Molecules, 2023 - mdpi.com
Neuronal injury and apoptosis are important causes of the occurrence and development of
many neurodegenerative diseases, such as cerebral ischemia, Alzheimer's disease, and …

Neuroprotective agents with therapeutic potential for COVID-19

CA Zaa, C Espitia, KL Reyes-Barrera, Z An… - Biomolecules, 2023 - mdpi.com
COVID-19 patients can exhibit a wide range of clinical manifestations affecting various
organs and systems. Neurological symptoms have been reported in COVID-19 patients …