Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Over the last decade, hydrogen sulfide (H 2 S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Hydrogen sulfide (H 2 S) is a member of the growing family of gasotransmitters. Once
regarded as a noxious molecule predominantly present in the atmosphere, H 2 S is now …

Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging
neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile …

Metabolism of excess methionine (Met) to homocysteine (Hcy) by transmethylation is
facilitated by the expression of methionine adenosyltransferase (MAT) I/III and glycine N …

Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking
its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO) …

The heme iron complex is one of the most important cofactors in biological systems (Figure
1). The major functions of the heme iron complex are to serve as the O2 binding site for …