The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE)
pathway is an important cell signaling mechanism in maintaining redox homeostasis in …

ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 are the
major players in drug efflux-mediated multidrug resistance (MDR), which severely affects the …

Ferroptosis, a recently discovered form of iron-dependent cell death, requires an increased
level of lipid-reactive oxygen species (ROS). Ferritinophagy, a ferritin degradation pathway …

In recent years, the interest in flavonoids as dietary bioactives to prevent human diseases,
as well as their candidacy as pharmaceutical leads, has exponentially expanded …

Cancer arises through a complex interplay between genetic, behavioral, metabolic, and
environmental factors that combined trigger cellular changes that over time promote …

Highlights•Flavonoids exhibit therapeutic potential against different types of cancer
cells.•Poor pharmacokinetics and biopharmaceutical traits limit their therapeutic …

Ascertaining whether dietary polyphenols evoke an antioxidant or prooxidant activity, which
translates to a functional role required to maintain intestinal cell homeostasis continues to be …

The quali-quantitative evaluation and the improvement of the levels of plant bioactive
secondary metabolites are increasingly gaining consideration by growers, breeders and …

Oral cancer continues to be a leading cause of death worldwide, and its prevalence is
particularly high in developing countries, where people chew tobacco and betel nut on a …

Cell cycle, growth, survival and metabolism are tightly regulated together and failure in
cellular regulation leads to carcinogenesis. Several signaling pathways like the PI3K, WNT …