This article reviews the current knowledge and recent advancements in computational
modeling of the cell cycle. It offers a comparative analysis of various modeling paradigms …

In this review, we discuss new emerging medical applications of the rapidly evolving field of
mammalian synthetic biology. We start with simple mammalian synthetic biological …

Different cancer cell lines can have varying responses to the same perturbations or stressful
conditions. Cancer cells that have DNA damage checkpoint-related mutations are often …

Background DNA damage (single or double-strand breaks) triggers adapted cellular
responses. These responses are elicited through signalling pathways, which activate cell …

Human cytomegalovirus (HCMV) is a major cause of illness in immunocompromised
individuals. The HCMV lytic cycle contributes to the clinical manifestations of infection. The …

This work aims to develop and validate a framework for the multiscale simulation of the
biological response to ionizing radiation in a population of cells forming a tissue. We present …

The tumor suppressor p53 protein shows various dynamic responses depending on the
types and extent of cellular stresses. In particular, in response to DNA damage induced by γ …

Atherosclerosis is a widespread and chronic progressive arterial disease that has been
regarded as one of the major causes of death worldwide. It is caused by the deposition of …

Cellular heterogeneity, which plays an essential role in biological phenomena, such as drug
resistance and migration, is considered to arise from intrinsic (ie, reaction kinetics) and …

The ability of a cell to conserve and maintain its native DNA sequence is fundamental for the
survival and normal functioning of the whole organism and protection from cancer …