Bone‐on‐a‐chip: microfluidic technologies and microphysiologic models of bone tissue

A Mansoorifar, R Gordon, RC Bergan… - Advanced functional …, 2021 - Wiley Online Library
Bone is an active organ that continuously undergoes an orchestrated process of remodeling
throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other …

Microfluidics and hydrogel: A powerful combination

CB Goy, RE Chaile, RE Madrid - Reactive and Functional Polymers, 2019 - Elsevier
Microfluidics is a very useful and promising technology that allowed engineering a huge
variety of developments in several fields, such as biology, biomedical engineering …

A bone‐on‐a‐chip collagen hydrogel‐based model using pre‐differentiated adipose‐derived stem cells for personalized bone tissue engineering

P Alamán‐Díez, E García‐Gareta… - … Research Part A, 2023 - Wiley Online Library
Mesenchymal stem cells have contributed to the continuous progress of tissue engineering
and regenerative medicine. Adipose‐derived stem cells (ADSC) possess many advantages …

Extracellular matrix density regulates the formation of tumour spheroids through cell migration

IG Gonçalves, JM Garcia-Aznar - PLoS computational biology, 2021 - journals.plos.org
In this work, we show how the mechanical properties of the cellular microenvironment
modulate the growth of tumour spheroids. Based on the composition of the extracellular …

Combined experimental and computational characterization of crosslinked collagen-based hydrogels

C Valero, H Amaveda, M Mora, JM García-Aznar - PLoS One, 2018 - journals.plos.org
Collagen hydrogels are widely used for in-vitro experiments and tissue engineering
applications. Their use has been extended due to their biocompatibility with cells and their …

From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β

J Plou, Y Juste-Lanas, V Olivares, C Del Amo… - Scientific reports, 2018 - nature.com
Cancer cells have the ability to migrate from the primary (original) site to other places in the
body. The extracellular matrix affects cancer cell migratory capacity and has been correlated …

Gel integration for microfluidic applications

X Zhang, L Li, C Luo - Lab on a Chip, 2016 - pubs.rsc.org
Molecular diffusive membranes or materials are important for biological applications in
microfluidic systems. Hydrogels are typical materials that offer several advantages, such as …

Surface patterning of hydrogel biomaterials to probe and direct cell–matrix interactions

BG Munoz‐Robles, I Kopyeva… - Advanced Materials …, 2020 - Wiley Online Library
Due to their mechanical and structural similarity to native tissues, hydrogel biomaterials
have gained tremendous popularity for applications in 3D tissue culture, therapeutic …

Topotactic fibrillogenesis of freeze-cast microridged collagen scaffolds for 3D cell culture

C Rieu, C Parisi, G Mosser, B Haye… - … applied materials & …, 2019 - ACS Publications
Type I collagen is the main component of the extracellular matrix (ECM). In vitro, under a
narrow window of physicochemical conditions, type I collagen self-assembles to form …

Moving through a changing world: single cell migration in 2D vs. 3D

A Pawluchin, M Galic - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Migration of single adherent cells is frequently observed in the developing and adult
organism and has been the subject of many studies. Yet, while elegant work has elucidated …