Gut-liver axis: Pathophysiological concepts and clinical implications

H Tilg, TE Adolph, M Trauner - Cell Metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

[HTML][HTML] Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Gut microbiome, liver immunology, and liver diseases

R Wang, R Tang, B Li, X Ma, B Schnabl… - Cellular & molecular …, 2021 - nature.com
The gut microbiota is a complex and plastic consortium of microorganisms that are intricately
connected with human physiology. The liver is a central immunological organ that is …

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

G Targher, CD Byrne, H Tilg - Gut, 2020 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …

[HTML][HTML] Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

F Violi, V Cammisotto, S Bartimoccia… - Nature reviews …, 2023 - nature.com
Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

[HTML][HTML] Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade

H Tilg, TE Adolph, AR Moschen - Hepatology, 2021 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is an epidemic liver disease, affecting
approximately one quarter of the entire population in the world.(1) This disease …

[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

K Pafili, M Roden - Molecular Metabolism, 2021 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …

[HTML][HTML] Gut microbiota metabolites in NAFLD pathogenesis and therapeutic implications

J Chen, L Vitetta - International journal of molecular sciences, 2020 - mdpi.com
Gut microbiota dysregulation plays a key role in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through its metabolites. Therefore, the restoration of the gut microbiota and …

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease

N Fujiwara, N Kubota, E Crouchet, B Koneru… - Science translational …, 2022 - science.org
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with
nonalcoholic fatty liver disease (NAFLD). In cohorts of 409 patients with NAFLD from …

The role of gut-derived lipopolysaccharides and the intestinal barrier in fatty liver diseases

L An, U Wirth, D Koch, M Schirren, M Drefs… - Journal of …, 2022 - Elsevier
Background Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty
(NAFLD) and alcoholic liver disease (ALD). As NAFLD is affecting 10–24% of the general …