Deubiquitinases: From mechanisms to their inhibition by small molecules
Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …
Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases
S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape
X Wu, M Go, JV Nguyen, NW Kuchel, BGC Lu… - Nature …, 2024 - nature.com
Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is
essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de …
essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de …
[HTML][HTML] Viral proteases as therapeutic targets
T Majerová, J Konvalinka - Molecular aspects of medicine, 2022 - Elsevier
Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …
herpesviruses―code for a protease, which is indispensable for viral maturation and …
VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains
SM Lange, MR McFarland, F Lamoliatte… - Nature Structural & …, 2024 - nature.com
Branched ubiquitin (Ub) chains constitute a sizable fraction of Ub polymers in human cells.
Despite their abundance, our understanding of branched Ub function in cell signaling has …
Despite their abundance, our understanding of branched Ub function in cell signaling has …
[HTML][HTML] Differences and similarities between innate immune evasion strategies of human coronaviruses
H Hoenigsperger, R Sivarajan, KMJ Sparrer - Current Opinion in …, 2024 - Elsevier
Highlights•Human coronaviruses use distinctand similar strategies to counteract innate
defenses.•Insights from SARS-CoV-2 will inspire research on endemic and epidemic …
defenses.•Insights from SARS-CoV-2 will inspire research on endemic and epidemic …
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
V Srinivasan, H Brognaro, PR Prabhu… - Communications …, 2022 - nature.com
Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site
VJE van Vliet, N Huynh, J Palà, A Patel, A Singer… - PLoS …, 2022 - journals.plos.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it
clear that combating coronavirus outbreaks benefits from a combination of vaccines and …
clear that combating coronavirus outbreaks benefits from a combination of vaccines and …
A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients
C Alteri, V Fox, R Scutari, GJ Burastero, S Volpi… - Communications …, 2022 - nature.com
Little is known about SARS-CoV-2 evolution under Molnupiravir and Paxlovid, the only
antivirals approved for COVID-19 treatment. By investigating SARS-CoV-2 variability in 8 …
antivirals approved for COVID-19 treatment. By investigating SARS-CoV-2 variability in 8 …
Molecular modelling and structure-activity relationship of a natural derivative of o-hydroxybenzoate as a potent inhibitor of dual NSP3 and NSP12 of SARS-CoV-2: In …
The nsp3 macrodomain and nsp12 (RdRp) enzymes are strongly implicated in the virulent
regulation of the host immune response and viral replication of SARS-CoV-2, making them …
regulation of the host immune response and viral replication of SARS-CoV-2, making them …