The identification of potential therapeutic agents for the treatment of epilepsy requires the
use of seizure models. Except for some early treatments, including bromides and …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …

We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-
1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability …

In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into
the market for the treatment of epilepsy using well-established preclinical seizure and …

Neuroinflammation is thought to contribute to the pathogenesis and maintenance of
temporal lobe epilepsy, but the underlying cell and molecular mechanisms are not fully …

For over 40 years, the National Institute of Neurological Disorders and Stroke/National
Institutes of Health-funded Anticonvulsant Screening Program has provided a preclinical …

Despite the progress made in the development of new antiepileptic drugs (AEDs), the
biggest challenges that epilepsy presents to drug development have remained unchanged …

Animal models of epilepsy and seizures, mostly involving mice and rats, are used to
understand the pathophysiology of the different forms of epilepsy and their comorbidities, to …

Zebrafish are a popular vertebrate model for human neurological disorders and drug
discovery. Although fecundity, breeding convenience, genetic homology and optical …