The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of
thousands of genes in a broad range of organisms in both normal physiological contexts …

Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter
the tumor microenvironment. To test whether exosomal RNAs also contribute to changes in …

Circular RNAs (circRNAs) represent a class of endogenous noncoding RNAs that have
recently been recognized as important regulators of gene expression and pathological …

Prostate cancer (PCa) is the most common cancer among men in developed countries.
Although its genetic background is thoroughly investigated, rather little is known about the …

Rates of production and degradation together specify microRNA (miRNA) abundance and
dynamics. Here, we used approach-to-steady-state metabolic labeling to assess these rates …

MicroRNAs (miRNAs) are transcriptional and posttranscriptional regulators involved in
nearly all known biological processes in distant eukaryotic clades. Their discovery and …

Pelteobagrus vachelli is a well-known commercial species in Asia. However, a sudden lack
of oxygen will result in mortality and eventually to pond turnover. Studying the molecular …

Spatiotemporal control of gene expression is central to animal development. Core promoters
represent a previously unanticipated regulatory level by interacting with cis-regulatory …

Background Development of sequencing technologies and supporting computation enable
discovery of small RNA molecules that previously escaped detection or were ignored due to …