Endometriosis is a chronic disease that affects about 10% of women of reproductive age. It
can contribute to pelvic pain, infertility or other conditions such as asthma, cardiovascular …

CD28 and CTLA-4 are both important stimulatory receptors for the regulation of T cell
activation. Because receptors share common ligands, B7. 1 and B7. 2, the expression and …

The immune response consists of a finely-tuned program, the activation of which must be
coupled with inhibitory mechanisms whenever initiated. This ensures tight control of …

Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is a critical negative regulator of
immune responses. Uniquely among known inhibitory receptors, its genetic ablation results …

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a key negative regulator of T cell activation. A
complex integration of positive and negative co-stimulatory signals in the well-defined B7 …

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory
molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down …

The discovery of multiple costimulatory cell surface molecules that influence the course of T
cell activation has increased our appreciation of the complexity of the T cell response. It …

Purpose Previously, we reported our experience treating 14 patients with metastatic
melanoma using a fully human antibody to cytotoxic T-lymphocyte antigen-4 (anti–CTLA-4) …

Macroscale biomaterials, such as preformed implantable scaffolds and injectable soft
materials, possess powerful synergies with anti-cancer immunotherapies. Immunotherapies …

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of T cell
responses. Germline Ctla4 deficiency is lethal, making investigation of the function of CTLA …