[HTML][HTML] Biological significance of agmatine, an endogenous ligand at imidazoline binding sites

W Raasch, U Schäfer, J Chun… - British journal of …, 2001 - ncbi.nlm.nih.gov
Abbreviations: ADC, arginine decarboxylase; AMPA, a-amino-3-hydroxy-5-methyl-4-
isoxazolepropionic acid; AP5,(+)-2-amino-5-phosphonopentanoic acid; APR, absolute …

Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence

S Regunathan - The AAPS journal, 2006 - Springer
Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme
arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine …

Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes

S Regunathan, JE Piletz - Annals of the New York Academy of …, 2003 - Wiley Online Library
Agmatine is a novel endogenous guanido amine synthesized from arginine by arginine
decarboxylase. Among several biologic effects, the ability of agmatine to protect against …

Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells

MY Zhu, JE Piletz, A Halaris, S Regunathan - Cellular and molecular …, 2003 - Springer
Aims: Agmatine is an endogenous guanido amine and has been shown to be
neuroprotective in vitro and in vivo. The aims of this study are to investigate whether …

Agmatine potentiates the analgesic effect of morphine by an α2-adrenoceptor-mediated mechanism in mice

Ö Yeşilyurt, IT Uzbay - Neuropsychopharmacology, 2001 - Elsevier
The effects of agmatine, which is an endogenous polyamine metabolite formed by
decarboxylation of L-arginine, and a combination of agmatine and morphine on tail-flick test …

Agmatine exerts anticonvulsant effect in mice: modulation by α2-adrenoceptors and nitric oxide

S Demehri, H Homayoun, H Honar, K Riazi, K Vafaie… - …, 2003 - Elsevier
The effect of agmatine, an endogenous polyamine metabolite, on seizure susceptibility was
investigated in mice. Acute intraperitoneal administration of agmatine (5, 10, 20, 40 mg/kg) …

The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice

L Moezi, H Shafaroodi, A Hojati, AR Dehpour - Epilepsy & Behavior, 2011 - Elsevier
Melatonin, the major hormone produced by the pineal gland, has a number of functions in
mammals, for example, its function as an anticonvulsant. Agmatine, a biogenic amine …

Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system

F Aricioglu, A Means, S Regunathan - European journal of pharmacology, 2004 - Elsevier
Agmatine is an endogenous amine derived from arginine that potentiates morphine
analgesia and blocks symptoms of naloxone-precipitated morphine withdrawal in rats. In this …

Agmatine potentiates morphine-induced conditioned place preference in mice: modulation by alpha (2)-adrenoceptors

P Tahsili-Fahadan, N Yahyavi-Firouz-Abadi… - …, 2006 - nature.com
The effects of agmatine, an endogenous polyamine metabolite formed by decarboxylation of
L-arginine, and its combination with morphine on conditioned place preference (CPP) has …

Imidazoline binding sites and receptors in cardiovascular tissue

GJ Molderings, M Göthert - General Pharmacology: The Vascular System, 1999 - Elsevier
Imidazoline binding sites and receptors and their endogenous ligands have been identified
in cardiovascular tissue of various species including human beings. 2. I 2-(but only …