Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

Background Tebentafusp, a T-cell receptor–bispecific molecule that targets glycoprotein 100
and CD3, is approved for adult patients who are positive for HLA-A* 02: 01 and have …

Background Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a
low tumor mutational burden and a 1-year overall survival of approximately 50% in patients …

In patients with previously treated metastatic uveal melanoma, the historical 1 year overall
survival rate is 37% with a median overall survival of 7.8 months. We conducted a …

Cutaneous melanoma remains the most lethal of the primary cutaneous neoplasms, and
although the incidence of primary melanoma continues to rise, the mortality from metastatic …

Advances in Melanoma Treatment The incidence of melanoma has increased, but mortality
has declined with improved management. Sentinel-node sampling has reduced morbidity …

Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

Abstract Background Immune checkpoint inhibitors (ICIs) have improved cancer outcomes.
However, immune-related adverse effects are common. The aim was to investigate the …

Preclinical studies have suggested that epigenetic therapy could enhance immunogenicity
of cancer cells. We report the results of the PEMDAC phase 2 clinical trial (n= 29; …