[HTML][HTML] Evaluating experimental, knowledge-based and computational cocrystal screening methods to advance drug-drug cocrystal fixed-dose combination …
Fixed-dose combinations (FDCs) offer significant advantages to patients and the
pharmaceutical industry alike through improved dissolution profiles, synergistic effects and …
pharmaceutical industry alike through improved dissolution profiles, synergistic effects and …
The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets
Amorphous solid dispersion (ASD) is an effective approach for enhancing the solubility,
dissolution, and bioavailability of poorly water-soluble drugs. However, these metastable …
dissolution, and bioavailability of poorly water-soluble drugs. However, these metastable …
Cocrystal prediction based on deep forest model—a case study of febuxostat
J Chen, Z Li, Y Kang, Z Li - Crystals, 2024 - mdpi.com
To aid cocrystal screening, a deep forest-based cocrystal prediction model was developed
in this study using data from the Cambridge Structural Database (CSD). The positive …
in this study using data from the Cambridge Structural Database (CSD). The positive …
Piperine as a molecular bridge mediates a ternary coamorphous system of polyphenols with enhanced pharmaceutical properties
J Ke, J Yuan, Z Pang, R Huang, W Miao… - International Journal of …, 2025 - Elsevier
The coamorphous formulations have attracted increasing interest due to enhanced solubility
and bioavailability, together with synergistic pharmacological effects. In this study, a ternary …
and bioavailability, together with synergistic pharmacological effects. In this study, a ternary …
Upscaling co-amorphous formulation of naringin-quinacrine dihydrochloride translating from laboratory to pilot scale using spray drying for improved physicochemical …
LP Katukam, AP Padakanti, N Chella - Powder Technology, 2025 - Elsevier
The current work focuses on improving the poor physicochemical and mechanical properties
of naringin (NRN) and quinacrine dihydrochloride (QDH) by formulating a co-amorphous …
of naringin (NRN) and quinacrine dihydrochloride (QDH) by formulating a co-amorphous …
Enhanced Dissolution and Bioavailability of Curcumin Nanocrystals Prepared by Hot Melt Extrusion Technology
Y Zhao, X Xu, A Dai, Y Jia, W Wang - International Journal of …, 2024 - Taylor & Francis
Purpose Curcumin nanocrystals (Cur-NCs) were prepared by hot melt extrusion (HME)
technology to improve the dissolution and bioavailability of curcumin (Cur). Methods Cur …
technology to improve the dissolution and bioavailability of curcumin (Cur). Methods Cur …
The new multidrug crystal of berberine and naringenin based on the couplet medicine of TCM: Crystal structure, physicochemical property, and synergistic anti-AD …
W Xiao, X Zou, L Zhang, R Shen, A Yang… - Journal of Molecular …, 2025 - Elsevier
A new multidrug crystal (MDC), composed of equimolar berberine (Ber) cation and
naringenin (Nar) anion, was designed and obtained based on the compatibility of the …
naringenin (Nar) anion, was designed and obtained based on the compatibility of the …
New bedaquiline salt with improved bioavailability and reduced food effect
X Zhang, D Meng, Z Zang, Z Xu, Y Liu - CrystEngComm, 2024 - pubs.rsc.org
Bedaquiline (BDQ) is an orally administered diarylquinoline class anti-tuberculosis drug
used in the combination therapy of MDR-TB. Currently, it is marketed as bedaquiline …
used in the combination therapy of MDR-TB. Currently, it is marketed as bedaquiline …
[PDF][PDF] 異なる分子間相互作用様式を持つ薬物-薬物コアモルファスの設計と膜透過性評価に関する研究
畑中友太 - 2024 - ompu.repo.nii.ac.jp
学 位 の 種 類 博士 (薬学) 学 位 記 番 号 甲博薬第 5 号学位授与の日付 令和 6 年 3 月 22
日学位授与の要件 学位規則第 4 条第 1 項該当学位論文題目 異なる分子間相互作用様式を持つ …
日学位授与の要件 学位規則第 4 条第 1 項該当学位論文題目 異なる分子間相互作用様式を持つ …