A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

Ischemic stroke is the second cause of mortality and the first cause of long-term disability
constituting a serious socioeconomic burden worldwide. Approved treatments include …

Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …

Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …

Abstract l‐glutamate is the predominant excitatory neurotransmitter in the CNS and has a
central role in a variety of brain functions. The termination of glutamate neurotransmission by …

Background: Stroke is one of the leading causes of death and disability worldwide and
places a heavy burden on the economy in our society. Current treatments, such as the use of …

Ischemic stroke is the leading cause of disability, but effective therapies are currently widely
lacking. Recovery from stroke is very much dependent on the possibility to develop …

Glutamate is the primary excitatory amino acid neurotransmitter in the CNS. The
concentration of glutamate in the synaptic cleft is tightly controlled by interplay between …

The ubiquitin–proteasome system (UPS) is a catalytic machinery that targets numerous
cellular proteins for degradation, thus being essential to control a wide range of basic …