[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
MicroRNA-based diagnosis and therapy
MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …
expression. Alteration in miRNA expression results in changes in the profile of genes …
Noncoding RNA therapeutics—challenges and potential solutions
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
miRNA: a promising therapeutic target in cancer
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …
complementarity pairing. Since discovery, they have been reported to be involved in a …
RNAi-based therapeutics and tumor targeted delivery in cancer
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …
for the development of targeted therapies for cancer and other diseases. The discovery of …
Current advances in RNA therapeutics for human diseases
H Zogg, R Singh, S Ro - International journal of molecular sciences, 2022 - mdpi.com
Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were
recognized as the genetic code containing the necessary information for proper cell …
recognized as the genetic code containing the necessary information for proper cell …
The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
RNA-based therapeutics: from antisense oligonucleotides to miRNAs
S Bajan, G Hutvagner - Cells, 2020 - mdpi.com
The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …
Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study
N Van Zandwijk, N Pavlakis, SC Kao, A Linton… - The Lancet …, 2017 - thelancet.com
Summary Background TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-
16-based mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract …
16-based mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract …
[HTML][HTML] How close are miRNAs from clinical practice? A perspective on the diagnostic and therapeutic market
E Bonneau, B Neveu, E Kostantin, GJ Tsongalis… - Ejifcc, 2019 - ncbi.nlm.nih.gov
The discovery of miRNAs in the mid-90s has changed the dogma of gene expression
regulation. Currently, miRNAs are the main theme of thousands of publications each year …
regulation. Currently, miRNAs are the main theme of thousands of publications each year …