Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …

Despite significant advances in pharmacologic therapy of depression over the past two
decades, a substantial proportion of patients fail to respond or experience only partial …

Chronic stress accounts for billions of dollars of economic loss annually in the United States
alone, and is recognized as a major source of disability and mortality worldwide. Robust …

Central dopaminergic and noradrenergic systems play essential roles in controlling several
forebrain functions. Consequently, perturbations of these neurotransmissions may contribute …

Purpose In routine practice, dopamine transporter (DAT) imaging is frequently used as a
diagnostic tool to support the diagnosis of Parkinson's disease or dementia with Lewy …

Abstract Background [123 I] N-ω-fluoropropyl-2β-carbomethoxy-3β-{4-iodophenyl}
nortropane ([123 I] FP-CIT) single photon emission computed tomography (SPECT) is a …

OBJECTIVE: To compare bupropion to placebo for reducing methamphetamine (MA) use,
increasing retention, and reducing the severity of depressive symptoms and MA-cravings. A …

A series of bupropion (1a) analogues (1b− 1ff) were synthesized, and their in vitro and in
vivo pharmacological properties evaluated with the goal of developing a 1a analogue that …

Bupropion is presumed to be a dopamine-norepinephrine reuptake inhibitor and is n
effective antidepressant. It is available as three oral formulations:(i) bupropion immediate …

The neural substrates of MDD (major depressive disorder) are complex and not yet fully
understood. In the present review, I provide a short overview of the findings supporting the …