Anthracycline-induced cardiotoxicity (AIC) is a serious and common side effect of
anthracycline therapy. Identification of genes and genetic variants associated with AIC risk …

Mitochondrion is a double membrane organelle that is responsible for cellular respiration
and production of most of the ATP in eukaryotic cells. Mitochondrial DNA (mtDNA) is the …

Mitochondria are central hubs for cellular metabolism, coordinating a variety of metabolic
reactions crucial for human health. Mitochondria provide most of the cellular energy via their …

Mitochondrial DNA (mtDNA) replication stalling is considered an initial step in the formation
of mtDNA deletions that associate with genetic inherited disorders and aging. However, the …

The unavailability of tractable reverse genetic analysis approaches represents an obstacle
to a better understanding of mitochondrial DNA replication. Here, we used CRISPR-Cas9 …

Mitochondria, the cell powerhouse, are membrane-bound organelles present in the
cytoplasm of almost all the eukaryotic cells. Their main function is to generate energy in the …

Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA
polymerase mitochondrial (POLRMT) serving as a key protein in regulating mitochondrial …

Faithful DNA replication is one of the most essential processes in almost all living
organisms. However, the proteins responsible for organellar DNA replication are still largely …

Mitochondria serve as the energy provider and enable life activities, and they are the only
organelles containing extra-chromosomal DNA. Each mitochondrion contains multiple …

To cope with DNA damage, mitochondria have developed a pathway whereby severely
damaged or unrepairable mitochondrial DNA (mtDNA) molecules can be discarded and …