Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

A wide spectrum of comorbidities has been associated with Parkinson's disease (PD), a
progressive neurodegenerative disease that affects more than seven million people …

Autophagy is a fundamental cellular process that is well conserved among eukaryotes. It is
one of the strategies that cells use to catabolize substances in a controlled way. Autophagy …

Background Blood-based gene expression or epigenetic biomarkers of Parkinson's disease
(PD) are highly desirable. However, accuracy and specificity need to be improved, and …

Two-pore channels (TPCs) are Ca 2+-permeable endo-lysosomal ion channels subject to
multi-modal regulation. They mediate their physiological effects through releasing Ca 2+ …

Neurodegenerative diseases are rarely caused by a mutation in a single gene but rather
influenced by a combination of genetic, epigenetic and environmental factors. Emerging …

Neurodegenerative diseases result in the progressive deterioration of the nervous system,
with motor and cognitive impairments being the two most observable problems. Motor …

Parkinson's disease (PD) is a neurodegenerative disorder involving progressive
deterioration of dopaminergic neurons. Although few genetic markers for familial PD are …

Parkinson's disease (PD) is a complex neurodegenerative disease with progressive loss of
dopamine neurons. PD patients usually manifest a series of motor and non-motor symptoms …

Alzheimer's disease (AD) and type 2 diabetes (T2D) are among the most prevalent chronic
diseases affecting the aging population. Extensive research evidence indicates that T2D is a …