HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

Functional selectivity is the term that describes drugs that cause markedly different signaling
through a single receptor (eg, full agonist at one pathway and antagonist at a second). It has …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

Since the first implant of a carbon microelectrode in a rat 35 years ago, there have been
substantial advances in the sensitivity, selectivity and temporal resolution of electrochemical …

In this review, the functional interactions between serotonin (5-HT) and dopamine (DA)
neuronal systems are discussed with the focus on microdialysis studies in the rodent brain …

The interaction between serotonin (5‐HT) and dopamine (DA)‐containing neurons in the
brain is a research topic that has raised the interest of many scientists working in the field of …

What percentage of receptors, ion channels or transporters must be occupied by drugs to
trigger therapeutic effects in patients, or by drugs and other ligands to induce physiological …

Considerable interest has arisen in identifying antipsychotic agents with improved efficacy
against negative symptoms, such as social withdrawal. In rats, a social interaction deficit can …

Serotonin 5-HT1A receptors are promising targets in the management of schizophrenia but
little information exists about affinity and efficacy of novel antipsychotics at these sites. We …