Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes, which have been
implicated in a number of physiological processes and in the pathogenesis of inflammatory …

12/15-Lipoxygenases (12/15-LOX) are members of the LOX family, which are expressed in
mammals by monocytes and macrophages following induction by the T helper type 2 …

Our laboratory is interested in understanding the regulation of NADPH oxidase activity in
human monocyte/macrophages. Protein kinase C (PKC) is reported to be involved in …

The Nrf2/antioxidant response element (ARE) signaling pathway plays a key role in
activating cellular antioxidants, including heme oxygenase-1 (HO-1), NADPH quinone …

Lipid mediators are bioactive metabolites of the essential polyunsaturated fatty acids (PUFA)
that play diverse roles in the initiation, self-limitation, and active resolution of inflammation …

Lipoxygenase (12/15-LO) catalyzes the oxidation of free and esterified fatty acids thereby
generating a whole spectrum of bioactive lipid mediators. This enzyme is involved in the …

Monocytes/macrophages are versatile cells centrally involved in host defense and immunity.
Th1 cytokines induce a classical activation program in monocytes/macrophages leading to a …

Macrophages are versatile cells involved in health and disease. These cells act as
scavengers to rid the body of apoptotic and senescent cells and debris through their …

Monoamine oxidase A (MAO-A) is a mitochondrial flavoenzyme implicated in the
pathogenesis of atherosclerosis and inflammation and also in many neurological disorders …

Purpose: The aim of the study was to determine the effect of inflammatory conditions on the
expression of tight junction (TJ) and adherens junction (AJ) proteins between human …