Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

J Aron-Wisnewsky, C Vigliotti, J Witjes, P Le… - Nature Reviews …, 2020 - nature.com
Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes
mellitus, two metabolic diseases strongly intertwined with non-alcoholic fatty liver disease …

The magnitude and progress of lean body mass, fat‐free mass, and skeletal muscle mass loss following bariatric surgery: a systematic review and meta‐analysis

MAH Nuijten, TMH Eijsvogels, VM Monpellier… - Obesity …, 2022 - Wiley Online Library
Postbariatric loss of muscle tissue could negatively affect long‐term health due to its role in
various bodily processes, such as metabolism and functional capacity. This meta‐analysis …

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

J Aron-Wisnewsky, E Prifti, E Belda, F Ichou, BD Kayser… - Gut, 2019 - gut.bmj.com
Objectives Decreased gut microbial gene richness (MGR) and compositional changes are
associated with adverse metabolism in overweight or moderate obesity, but lack …

Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD

M Weber, P Mera, J Casas, J Salvador… - … of American Societies …, 2020 - repositori.uic.es
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to
the global obesity pandemic but at present there are no approved therapies. Here, we aimed …

Longitudinal changes of microbiome composition and microbial metabolomics after surgical weight loss in individuals with obesity

N Shen, A Caixàs, M Ahlers, K Patel, Z Gao… - Surgery for obesity and …, 2019 - Elsevier
Background Some of the metabolic effects of bariatric surgery may be mediated by the gut
microbiome. Objectives To study the effect of bariatric surgery on changes to gut microbiota …

Sphingolipid metabolism and signaling in skeletal muscle: from physiology to physiopathology

S Tan-Chen, J Guitton, O Bourron, H Le Stunff… - Frontiers in …, 2020 - frontiersin.org
Sphingolipids represent one of the major classes of eukaryotic lipids. They play an essential
structural role, especially in cell membranes where they also possess signaling properties …

Metabolomic signatures after bariatric surgery–a systematic review

M Vaz, SS Pereira, MP Monteiro - Reviews in Endocrine and Metabolic …, 2022 - Springer
Metabolomics emerged as an important tool to gain insights on how the body responds to
therapeutic interventions. Bariatric surgery is the most effective treatment for severe obesity …

The metabolomic effects of tripeptide gut hormone infusion compared to Roux-en-Y gastric bypass and caloric restriction

B Jones, C Sands, K Alexiadou… - The Journal of …, 2022 - academic.oup.com
Context The gut-derived peptide hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin
(OXM), and peptide YY (PYY) are regulators of energy intake and glucose homeostasis and …

The lard works in mysterious ways: ceramides in nutrition-linked chronic disease

RJ Nicholson, MK Norris, AM Poss… - Annual review of …, 2022 - annualreviews.org
Diet influences onset, progression, and severity of several chronic diseases, including heart
failure, diabetes, steatohepatitis, and a subset of cancers. The prevalence and clinical …

Changes in blood microRNA expression and early metabolic responsiveness 21 days following bariatric surgery

SL Atkin, V Ramachandran, NA Yousri… - Frontiers in …, 2019 - frontiersin.org
Background: Early metabolic responses following bariatric surgery appear greater than
expected given the initial weight loss and coincide with improvement in diabetes. We …