N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Although carbon is the central element of organic chemistry, oxygen is the central element of
stereoelectronic control in organic chemistry. Generally, a molecule with a C–O bond has …

Metabolism has historically been studied at the levels of whole cells, whole tissues and
whole organisms. As a result, our understanding of how compartmentalization—the spatial …

Mechanisms that integrate the metabolic state of a cell with regulatory pathways are
necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites …

Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Packaging the long and fragile genomes of eukaryotic species into nucleosomes is all well
and good, but how do cells gain access to the DNA again after it has been bundled away …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …