Metabolomics use in toxicology is rapidly increasing, particularly owing to advances in mass
spectroscopy, which is widely used in the life sciences for phenotyping disease states …

Metabolic engineering tools have been widely applied to living organisms to gain a
comprehensive understanding about cellular networks and to improve cellular properties …

Cultured cell lines are useful models in biomedical research that characterize metabolic
responses to various stimuli (eg, pathogens, toxins, or drugs/chemicals) and explore the …

Since the publication of REACH guidelines, the need for in vitro tools for toxicity testing has
increased. We present here the development of a hepatotoxicity testing tool using human …

Triadimefon (TDF) is a triazole-derivative fungicide that is detectable in the environment and
target agricultural products, prompting concern over its risk to wildlife and human health. In …

The electrochemical oxidation (EO) treatment in water of three conazole fungicides,
myclobutanil, triadimefon and propiconazole, has been carried out at constant current using …

Penconazole is a systemic triazole fungicide mainly used on grapes. The UE Maximum
Residue Level (MRL) for penconazole is set at 0.2 ppm in wine and grapes. In the aim of …

Methotrexate is an immunosuppressive and antineoplastic drug that may induce
hepatotoxicity. Resveratrol is a compound that has a protective effect thanks to its …

Isolated liver perfusion systems have been extensively used to characterize intrinsic
metabolic changes in liver under various conditions, including systemic injury, hepatotoxin …

11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive 11-
oxo glucocorticoids (endogenous cortisone, 11-dehydrocorticosterone and synthetic …