Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder
producing progressive cognitive decline that interferes with normal life and daily activities …

Super-resolution fluorescence imaging by photoactivation or photoswitching of single
fluorophores and position determination (single-molecule localization microscopy, SMLM) …

Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Abstract α-synuclein (αS) is an intrinsically disordered protein whose fibrillar aggregates are
the major constituents of Lewy bodies in Parkinson's disease. Although the specific function …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Parkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy
Bodies and Lewy Neurites containing α-synuclein fibrils. The underlying aggregation …

Both oxidative stress and neurotoxicity are huge challenges to human health, and effective
methods and agents for resisting these adverse effects are limited, especially in vivo. It is …

Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

Protein aggregation is a hallmark of major neurodegenerative disorders. Increasing data
suggest that smaller aggregates cause higher toxic response than filamentous aggregates …

Amyloid fibrils are β-sheet-rich linear protein polymers that can be formed by a large variety
of different proteins. These assemblies have received much interest in recent decades, due …