Sarcoma treatment in the era of molecular medicine

TGP Grünewald, M Alonso, S Avnet… - EMBO molecular …, 2020 - embopress.org
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Cancer stem cells as a source of drug resistance in bone sarcomas

ST Menéndez, B Gallego, D Murillo… - Journal of Clinical …, 2021 - mdpi.com
Bone sarcomas are commonly characterized by a high degree of intra-tumor heterogeneity,
which in part is due to the presence of subpopulations of tumor cells presenting stem cell …

Temperature monitoring in hyperthermia treatments of bone tumors: State-of-the-art and future challenges

F De Tommasi, C Massaroni, RF Grasso, M Carassiti… - Sensors, 2021 - mdpi.com
Bone metastases and osteoid osteoma (OO) have a high incidence in patients facing
primary lesions in many organs. Radiotherapy has long been the standard choice for these …

Emerging Trends in Immunotherapy for Adult Sarcomas

M Husain, L Chen, D Liebner, J Beane… - The …, 2023 - academic.oup.com
Soft-tissue sarcomas (STS) are a rare and heterogeneous group of malignant tumors that
arise from the oncogenic transformation of mesenchymal tissue. There are over 100 distinct …

A survey on deep learning and machine learning techniques over histopathology image based Osteosarcoma Detection

KV Deepak, R Bharanidharan - Multimedia Tools and Applications, 2024 - Springer
Osteosarcoma is a common type of cancer that occurs in the cells and spreads to the bones.
Osteosarcoma can develop due to genetic mutations, but most cases are not inherited. It …

Addressing doxorubicin resistance in bone sarcomas using novel drug-resistant models

B Gallego, D Murillo, V Rey, C Huergo… - International journal of …, 2022 - mdpi.com
Bone sarcomas have not shown a significant improvement in survival for decades, due, in
part, to the development of resistance to current systemic treatments, such as doxorubicin …

Transcriptional regulation and therapeutic potential of cyclin-dependent kinase 9 (CDK9) in sarcoma

RL Walker, FJ Hornicek, Z Duan - Biochemical Pharmacology, 2024 - Elsevier
Sarcomas include various subtypes comprising two significant groups–soft tissue and bone
sarcomas. Although the survival rate for some sarcoma subtypes has improved over time …

Proof of concept for the use of trained sniffer dogs to detect osteosarcoma

A Ortal, A Rodríguez, MP Solis-Hernández… - Scientific Reports, 2022 - nature.com
Sarcomas are mesenchymal cancers which often show an aggressive behavior and patient
survival largely depends on an early detection. In last years, much attention has been given …

[HTML][HTML] Arid1a Loss Enhances Disease Progression in a Murine Model of Osteosarcoma

K Fatema, Y Wang, A Pavek, Z Larson, C Nartker… - Cancers, 2024 - mdpi.com
Simple Summary Osteosarcoma is an aggressive form of bone cancer that spreads quickly
and is challenging to treat. Genetic screening in this study discovered that the loss of the …

Enhancing Accuracy in the Detection of Chondrosarcoma Using Mobile Net Algorithm and Comparison with Support Vector Machine

AB Veekshith, TJ Nagalakshmi - 2024 Ninth International …, 2024 - ieeexplore.ieee.org
A new chondrosarcoma detection system was developed by comparing the mobilenet
algorithm with the use of deep learning's SVM. Accuracy was the criterion used to evaluate …