[HTML][HTML] Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
[HTML][HTML] Regulatory SNPs: altered transcription factor binding sites implicated in complex traits and diseases
AO Degtyareva, EV Antontseva… - International journal of …, 2021 - mdpi.com
The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …
and diseases map to a noncoding part of the genome and are enriched in its regulatory …
'Fly-ing'from rare to common neurodegenerative disease mechanisms
Advances in genome sequencing have enabled researchers and clinicians to probe vast
numbers of human variants to distinguish pathogenic from benign variants. Model …
numbers of human variants to distinguish pathogenic from benign variants. Model …
[HTML][HTML] A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
Background Genome-wide association studies (GWAS) have identified over 56 susceptibility
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
[HTML][HTML] A splicing transcriptome-wide association study identifies novel altered splicing for Alzheimer's disease susceptibility
Alzheimer's disease (AD) is a common neurodegenerative disease in aging individuals.
Alternative splicing is reported to be relevant to AD development while their roles in etiology …
Alternative splicing is reported to be relevant to AD development while their roles in etiology …
[HTML][HTML] Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk
G Novikova, SJ Andrews, AE Renton… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is the most common type of dementia, affecting millions of people
worldwide; however, no disease-modifying treatments are currently available. Genome-wide …
worldwide; however, no disease-modifying treatments are currently available. Genome-wide …
Integrative network-based analysis reveals gene networks and novel drug repositioning candidates for Alzheimer disease
ZF Gerring, ER Gamazon, A White… - Neurology: Genetics, 2021 - AAN Enterprises
Background and Objectives To integrate genome-wide association study data with tissue-
specific gene expression information to identify coexpression networks, biological pathways …
specific gene expression information to identify coexpression networks, biological pathways …
[HTML][HTML] Identification of candidate DNA methylation biomarkers related to Alzheimer's disease risk by integrating genome and blood methylome data
Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is
critical to identify novel blood-based DNA methylation biomarkers to better understand the …
critical to identify novel blood-based DNA methylation biomarkers to better understand the …
[HTML][HTML] Gene therapy for neurodegenerative disease: clinical potential and directions
X Zhu, Y Zhang, X Yang, C Hao… - Frontiers in Molecular …, 2021 - frontiersin.org
The pathogenesis of neurodegenerative diseases (NDDs) is complex and diverse. Over the
decades, our understanding of NDD has been limited to pathological features. However …
decades, our understanding of NDD has been limited to pathological features. However …
[HTML][HTML] Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer's disease
Genome-wide association studies (GWASs) have identified multiple susceptibility loci for
Alzheimer's disease (AD), which is characterized by early and progressive damage to the …
Alzheimer's disease (AD), which is characterized by early and progressive damage to the …