Nearly one-third of patients with epilepsy continue to have seizures despite optimal
medication management. Systems employed to detect seizures may have the potential to …

Background Genetic rat models for childhood absence epilepsy have become instrumental
in developing theories on the origin of absence epilepsy, the evaluation of new and …

An 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG
(iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic …

The ultimate goal of epileptology is the complete abolishment of epileptic seizures. This
might be achieved by a system that predicts seizure onset combined with a system that …

Implantable devices for electrical stimulation of the brain have been in routine clinical use
since 1997, when the first commercial deep brain stimulation (DBS) system was approved …

The ultimate goal of epilepsy therapies is to provide seizure control for all patients while
eliminating side effects. Improved specificity of intervention through on-demand approaches …

Objective. Closed-loop operation of neuro-electronic systems is desirable for both scientific
and clinical (neuroprosthesis) applications. Integrating optical stimulation with recording …

In this paper, we investigate the abatement of spike-and-wave discharges in a
thalamocortical model using a closed-loop brain stimulation method. We first explore the …

Epilepsy is a complex disorder involving neurological alterations that lead to the
pathological development of spontaneous, recurrent seizures. For decades, seizures were …

This article investigates a closed-loop brain stimulation method based on model predictive
control strategy to suppress epileptic seizures. A neural mass model (NMM), exhibiting the …