Despite the advent of sophisticated and efficient new biologics to treat inflammation in
asthma, the disease persists. Even following treatment, many patients still experience the …

Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Allergic asthma has traditionally been treated with inhaled and systemic
glucocorticosteroids. A continuum of allergic fungal airways disease associated with …

The unified airway hypothesis proposes that upper and lower airway diseases reflect a
single pathological process manifesting in different locations within the airway. Functional …

Spontaneous protein crystallization is a rare event, yet protein crystals are frequently found
in eosinophil-rich inflammation. In humans, Charcot-Leyden crystals (CLCs) are made from …

Abstract Background Charcot‐Leyden crystals (CLCs) are recognized to be classic
hallmarks of eosinophilic inflammation. Both protein and mRNA levels of CLC in nasal …

This review highlights recent advances in the understanding of eosinophils and eosinophilic
diseases, particularly eosinophilic gastrointestinal diseases during the last year. The …

Major progress has been achieved in the understanding and clinical practice of chronic
rhinosinusitis, with or without nasal polyps. These advances resulted in a better …

Traditionally, eosinophils have been linked to parasitic infections and pathological disease
states. However, emerging literature has unveiled a more nuanced and intricate role for …

Abstract Purpose of Review Chronic rhinosinusitis (CRS) is a complicated, heterogeneous
disease likely caused by inflammatory and infectious factors. There is clear evidence that …