Genome regulation by long noncoding RNAs
The central dogma of gene expression is that DNA is transcribed into messenger RNAs,
which in turn serve as the template for protein synthesis. The discovery of extensive …
which in turn serve as the template for protein synthesis. The discovery of extensive …
Alternative cleavage and polyadenylation: extent, regulation and function
The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
TAIL-seq: genome-wide determination of poly (A) tail length and 3′ end modifications
Global investigation of the 3′ extremity of mRNA (3′-terminome), despite its importance in
gene regulation, has not been feasible due to technical challenges associated with …
gene regulation, has not been feasible due to technical challenges associated with …
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
The mechanisms by which the p53 tumor suppressor acts remain incompletely understood.
To gain new insights into p53 biology, we used high-throughput sequencing to analyze …
To gain new insights into p53 biology, we used high-throughput sequencing to analyze …
Endogenous retroviruses function as species-specific enhancer elements in the placenta
The mammalian placenta is remarkably distinct between species, suggesting a history of
rapid evolutionary diversification. To gain insight into the molecular drivers of placental …
rapid evolutionary diversification. To gain insight into the molecular drivers of placental …
[HTML][HTML] The poly (A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites
Alternative cleavage and polyadenylation (APA) is emerging as an important layer of gene
regulation. Factors controlling APA are largely unknown. We developed a reporter-based …
regulation. Factors controlling APA are largely unknown. We developed a reporter-based …
A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on …
Alternative polyadenylation (APA) is a general mechanism of transcript diversification in
mammals, which has been recently linked to proliferative states and cancer. Different 3 …
mammals, which has been recently linked to proliferative states and cancer. Different 3 …
Fragaria: A genus with deep historical roots and ripe for evolutionary and ecological insights
The cultivated strawberry, Fragaria× ananassa, is one of the youngest domesticated plants.
Its 18th century origin via hybridization in Europe between the North American F. virginiana …
Its 18th century origin via hybridization in Europe between the North American F. virginiana …
Cleavage and polyadenylation: Ending the message expands gene regulation
J Neve, R Patel, Z Wang, A Louey, AM Furger - RNA biology, 2017 - Taylor & Francis
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
Widespread intronic polyadenylation diversifies immune cell transcriptomes
Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region
(3ʹUTR) length but can also recognize intronic polyadenylation (IpA) signals to generate …
(3ʹUTR) length but can also recognize intronic polyadenylation (IpA) signals to generate …