A century ago, Cajal noted striking similarities between the neural circuits that underlie
vision in vertebrates and flies. Over the past few decades, structural and functional studies …

In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent
progenitors in a conserved order and are integrated into an intricate laminated architecture …

In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of
cone function is a major therapeutic goal. However, cone loss is thought to occur as a …

Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …

The vertebrate retina is a well-characterized and tractable model for studying neurogenesis.
Retinal neurons and glia are generated in a conserved sequence from a pool of multipotent …

Humans rely on visual cues to navigate the world around them. Vision begins with the
detection of light by photoreceptor cells in the retina, a light-sensitive tissue located at the …

Photoreceptors–the light-sensitive cells in the vertebrate retina–have been extremely well-
characterized with regards to their biochemistry, cell biology and physiology. They therefore …

The derivation of three-dimensional (3D) stratified neural retina from pluripotent stem cells
has permitted investigations of human photoreceptors. We have generated a H9 human …

Transcriptional regulatory networks that control the morphologic and functional diversity of
mammalian neurons are still largely undefined. Here we dissect the roles of the highly …

Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in
jawless vertebrates with the advent of highly photosensitive rod-like photoreceptors. Despite …