Effector-triggered immunity
The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …
Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis
KS Robinson, GA Toh, MJ Firdaus, KC Tham… - Journal of Experimental …, 2023 - rupress.org
The ZAKα-driven ribotoxic stress response (RSR) is activated by ribosome stalling and/or
collisions. Recent work demonstrates that RSR also plays a role in innate immunity by …
collisions. Recent work demonstrates that RSR also plays a role in innate immunity by …
Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria
KS ROBINSON, GA TOH, MJ FIRDAUS, KC THAM… - bioRxiv, 2023 - biorxiv.org
ABSTRACT NLRP1 is an innate immune sensor protein that activates inflammasome-driven
pyroptotic cell death. Recent work demonstrates that human NLRP1 has evolved to sense …
pyroptotic cell death. Recent work demonstrates that human NLRP1 has evolved to sense …