Human type I interferon antiviral effects in respiratory and reemerging viral infections

PL Acosta, AB Byrne, DR Hijano… - Journal of immunology …, 2020 - Wiley Online Library
Type I interferons (IFN‐I) are a group of related proteins that help regulate the activity of the
immune system and play a key role in host defense against viral infections. Upon infection …

Neuroimaging of emergent and reemergent infections

RL Carmo, AK Alves Simao, LLF Amaral, BSY Inada… - Radiographics, 2019 - pubs.rsna.org
Infectious diseases emerge and reemerge over the years, and many of them can cause
neurologic disease. Several factors contribute to the emergence and reemergence of these …

Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors

CS Lima, M Mottin, LR de Assis, NCMR Mesquita… - Bioorganic …, 2021 - Elsevier
Although the widespread epidemic of Zika virus (ZIKV) and its neurological complications
are well-known there are still no approved drugs available to treat this arboviral disease or …

[HTML][HTML] Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models

D Yang, XJ Li, DZ Tu, XL Li, B Wei - Zoological Research, 2023 - ncbi.nlm.nih.gov
Viral infections have led to many public health crises and pandemics in the last few
centuries. Neurotropic virus infection-induced viral encephalitis (VE), especially the …

[HTML][HTML] Neutrophil and macrophage influx into the central nervous system are inflammatory components of lethal Rift Valley fever encephalitis in rats

JR Albe, DA Boyles, AW Walters, MR Kujawa… - PLoS …, 2019 - journals.plos.org
Rift Valley fever virus (RVFV) causes severe disease in livestock concurrent with zoonotic
transmission to humans. A subset of people infected with RVFV develop encephalitis, and …

[HTML][HTML] Molecular and Cellular Mechanisms Underlying Neurologic Manifestations of Mosquito-Borne Flavivirus Infections

BM Blackhurst, KE Funk - Viruses, 2023 - mdpi.com
Flaviviruses are a family of enveloped viruses with a positive-sense RNA genome,
transmitted by arthropod vectors. These viruses are known for their broad cellular tropism …

[HTML][HTML] Riboflavin, a potent neuroprotective vitamin: focus on flavivirus and alphavirus proteases

RJ Eberle, DS Olivier, MS Amaral, CC Pacca… - Microorganisms, 2022 - mdpi.com
Several neurotropic viruses are members of the flavivirus and alphavirus families. Infections
caused by these viruses may cause long-term neurological sequelae in humans. The …

[HTML][HTML] Neutrophil Recruitment and Participation in Severe Diseases Caused by Flavivirus Infection

MA Fontoura, RF Rocha, RE Marques - Life, 2021 - mdpi.com
Neutrophils are first-line responders to infections and are recruited to target tissues through
the action of chemoattractant molecules, such as chemokines. Neutrophils are crucial for the …

Type I interferons are essential while type II interferon is dispensable for protection against St. Louis encephalitis virus infection in the mouse brain

RF Rocha, JL Del Sarto, GF Gomes, MP Gonçalves… - Virulence, 2021 - Taylor & Francis
St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne flavivirus that causes
severe neurological disease in humans. SLEV replication in the central nervous system …

[HTML][HTML] Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina

ME Rivarola, S de Olmos, G Albrieu-Llinás… - Frontiers in …, 2018 - frontiersin.org
Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe
neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an …