The RNA helicase DDX39A binds a conserved structure in Chikungunya virus RNA to control infection
Alphaviruses are a large group of re-emerging arthropod-borne RNA viruses. The compact
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …
The role of the NF-kB pathway in intracranial aneurysms
The pathophysiology of intracranial aneurysms (IA) has been proven to be closely linked to
hemodynamic stress and inflammatory pathways, most notably the NF-kB pathway …
hemodynamic stress and inflammatory pathways, most notably the NF-kB pathway …
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity
The sensing of nucleic acids by DEAD/H‐box helicases, specifically retinoic acid‐inducible
gene I (RIG‐I) and melanoma differentiation‐associated protein 5 (MDA5), plays a critical …
gene I (RIG‐I) and melanoma differentiation‐associated protein 5 (MDA5), plays a critical …
Calmodulin triggers activity-dependent rRNA biogenesis via interaction with DDX21
JL Yang, X Sun, JX Shi, QX Cui, XY Cao… - Journal of …, 2024 - jneurosci.org
Protein synthesis in response to neuronal activity, known as activity-dependent translation,
is critical for synaptic plasticity and memory formation. However, the signaling cascades that …
is critical for synaptic plasticity and memory formation. However, the signaling cascades that …
Endogenous ZAP affects Zika virus RNA interactome
One of the most recent advances in the analysis of viral RNA-cellular protein interactions is
the Comprehensive Identification of RNA-binding Proteins by Mass Spectrometry (ChIRP …
the Comprehensive Identification of RNA-binding Proteins by Mass Spectrometry (ChIRP …
HSV-1 infection induces a downstream shift of promoter-proximal pausing for host genes
E Weiß, T Hennig, P Graßl, L Djakovic… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) infection exerts a profound shutoff of host gene
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …
[HTML][HTML] DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs
Glucose binding can alter protein oligomerization to enable differentiation. Here, we
demonstrate that glucose binding is a general capacity of DExD/H-box RNA helicases …
demonstrate that glucose binding is a general capacity of DExD/H-box RNA helicases …
HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
Histone deacetylases (HDACs) regulate gene expression and innate immunity. Previously,
we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a …
we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a …
Endogenous ZAP is associated with altered Zika virus infection phenotype
The zinc finger antiviral protein 1 (ZAP) has broad antiviral activity. ZAP is an interferon (IFN)-
stimulated gene, which itself may enhance type I IFN antiviral response. In a previous study …
stimulated gene, which itself may enhance type I IFN antiviral response. In a previous study …
Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer
B Zheng, X Chen, Q Ling, Q Cheng, S Ye - Frontiers in Oncology, 2023 - frontiersin.org
Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-
related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately …
related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately …