The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Activation of complex molecular programs in specific cell lineages governs mammalian
heart development, from a primordial linear tube to a four-chamber organ. To characterize …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Communication is important to ensure the correct and efficient flow of information, which is
required to sustain active social networks. A fine-tuned communication between cells is vital …

Cells of multicellular organisms need to communicate with each other and have evolved
various mechanisms for this purpose, the most direct and quickest of which is through …

Gap junctions (GJs) channels provide the basis for intercellular communication in the
cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular …

The cardiac sodium current (INa) is responsible for the rapid depolarization of cardiac cells,
thus allowing for their contraction. It is also involved in regulating the duration of the cardiac …

Brugada syndrome is an inherited disease characterized by an increased risk of sudden
cardiac death owing to ventricular arrhythmias in the absence of structural heart disease …

BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is closely associated with
desmosomal mutations in a majority of patients. Arrhythmogenesis in patients with AC is …