Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

YN Zhang, W Poon, AJ Tavares, ID McGilvray… - Journal of controlled …, 2016 - Elsevier
99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

H Mekaru, J Lu, F Tamanoi - Advanced drug delivery reviews, 2015 - Elsevier
Nanoparticles that respond to internal and external stimuli to carry out controlled release of
anticancer drugs have been developed. In this review, we focus on the development of …

[HTML][HTML] Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: current status and uses

PI Siafaka, N Üstündağ Okur, E Karavas… - International journal of …, 2016 - mdpi.com
Nanocarriers, due to their unique features, are of increased interest among researchers
working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules …

Targeting tumor associated macrophages (TAMs) via nanocarriers

Y Singh, VK Pawar, JG Meher, K Raval, A Kumar… - Journal of Controlled …, 2017 - Elsevier
Recruitment of inflammatory cells to tumor has been well documented, with the most
frequent inhabitants being macrophages termed as tumor associated macrophages,(TAMs) …

Improved chemotherapy against breast cancer through immunotherapeutic activity of fucoidan decorated electrostatically assembled nanoparticles bearing …

VK Pawar, Y Singh, K Sharma, A Shrivastav… - International journal of …, 2019 - Elsevier
Immunotherapeutic nanoparticles (NPs) could be a viable option for delivering cytotoxic
agents in a manner which suppresses their toxic manifestations. Doxorubicin (DOX) loaded …

Choline derivate-modified doxorubicin loaded micelle for glioma therapy

J Li, H Yang, Y Zhang, X Jiang, Y Guo… - … Applied Materials & …, 2015 - ACS Publications
Ligand-mediated polymeric micelles have enormous potential for improving the efficacy of
glioma therapy. Linear–dendritic drug–polymer conjugates composed of doxorubicin (DOX) …

Nanocarriers-mediated therapeutics as a promising approach for treatment and diagnosis of lung cancer

K Kumar, R Chawla - Journal of Drug Delivery Science and Technology, 2021 - Elsevier
Lung cancer is one of the most chronic forms of cancer that causes cancer-related mortality
globally. The current treatment therapy includes chemotherapy, radiation/bio therapy, and …

Self‐Assembled Fluorescent Nanoparticles from π‐Conjugated Small Molecules: En Route to Biological Applications

J Schill, APHJ Schenning… - Macromolecular Rapid …, 2015 - Wiley Online Library
Since the development of supramolecular chemical biology, self‐organised nano‐
architectures have been widely explored in a variety of biomedical applications …

A facile way to improve the bioavailability of nanomedicine based on the threshold theory

H Zhang, P Cui, Z Gao, S Zhou, C Wang… - Molecular …, 2022 - ACS Publications
One of the most significant barriers to the clinical transformation of nanomedicines is low
drug distribution in solid tumors due to quick clearance of nanomedicine after injection …

Multistage passive and active delivery of radiolabeled nanogels for superior tumor penetration efficiency

N Drude, S Singh, OH Winz, M Möller… - …, 2017 - ACS Publications
Development of nanosized drug delivery systems in cancer therapy is directed toward
improving tumor selectivity and minimizing damages of healthy tissue. We introduce a …