Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Chagas' disease is a major parasitic problem in developing countries in Central and South
America. Chemotherapy for such disease is still insufficient and not effective in its chronic …

The syntheses of a new series of derivatives of 1, 2, 5-oxadiazole N-oxide, benzo [1, 2-c] 1,
2, 5-oxadiazole N-oxide, and quinoxaline di-N-oxide are described. In vitro …

The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the
protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis …

Several novel semicarbazone derivatives were prepared from 5-nitro-2-furaldehyde or 5-
nitrothiophene-2-carboxaldehyde and semicarbazides bearing a spermidine-mimetic …

Chagas disease represents a serious public health problem in South America. The first line
of treatment is Nifurtimox and Benznidazole which generate toxic effects in treated patients …

In the search for new therapeutic tools for the treatment of American trypanosomiasis, a
series of novel ferrocene and cyrhetrene imine compounds, derived from 5-nitro …

Nifurtimox is a nitroheterocyclic drug employed for treatment of trypanosomiases (Chagas
disease and West African sleeping sickness); its use for certain cancers has also been …

In the search of new therapeutic tools for the treatment of American Trypanosomiasis, the
largest parasitic disease burden in the American continent, three series of novel ruthenium …

Several new 1, 2, 5-oxadiazole N-oxide derivatives and some deoxygenated analogues
were synthesized to be tested as potential selective hypoxic cell cytotoxins. Compounds …