Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …

During the past decades, lipid nanocarriers are gaining momentum with their multiple
advantages for the management of skin diseases. Lipid nanocarriers enable to target the …

INTRODUCTION Studies of monogenic diseases have uncovered the importance of immune
pathways in human tissue-specific immunity and antimicrobial defense. In particular, human …

Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in
both hospital and community settings, especially with the widespread emergence of virulent …

Antibiotics are a modifiable iatrogenic risk factor for the most common human nosocomial
fungal infection, invasive candidiasis, yet the underlying mechanisms remain elusive. We …

Heterozygous gain-of-function (GOF) mutations in STAT1 in patients with chronic
mucocutaneous candidiasis (CMC) and hypothyroidism were discovered in 2011. CMC is …

The oral mucosa is a primary barrier site and a portal for entry of microbes, food, and
airborne particles into the gastrointestinal tract. Nonetheless, mucosal immunity at this …