Autophagy genes in biology and disease
H Yamamoto, S Zhang, N Mizushima - Nature Reviews Genetics, 2023 - nature.com
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …
Neutrophils: from IBD to the gut microbiota
C Danne, J Skerniskyte, B Marteyn… - Nature Reviews …, 2024 - nature.com
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …
with a major genetic component. Here, we present a genome-wide association study meta …
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …
Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study
Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's
disease (CD). OS-related genes can be affected by environmental factors, intestinal …
disease (CD). OS-related genes can be affected by environmental factors, intestinal …
Neutralizing autoantibodies against interleukin-10 in inflammatory bowel disease
H Griffin, L Ceron-Gutierrez… - … England Journal of …, 2024 - Mass Medical Soc
We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with
infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin …
infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin …
Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults
L Yang, YN Ou, BS Wu, WS Liu, YT Deng… - Nature …, 2024 - nature.com
The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs)
remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK …
remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK …
Common genetic factors among autoimmune diseases
Autoimmune diseases display a high degree of comorbidity within individuals and families,
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease
Inflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by
episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system …
episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system …
[HTML][HTML] Defining interactions between the genome, epigenome, and the environment in inflammatory bowel disease: progress and prospects
Recent advances in our understanding of the pathogenesis of inflammatory bowel disease
(IBD) have highlighted the complex interplay between the genome, the epigenome, and the …
(IBD) have highlighted the complex interplay between the genome, the epigenome, and the …