The majority of the DNA sequence in our genome is noncoding and not intended for
synthesizing proteins. Nonetheless, genome-wide mapping of ribosome footprints has …

The unfolded protein response (UPR) in plants is elicited by endoplasmic reticulum stress,
which can be brought about by adverse environmental conditions. The response is …

Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a
series of quality control events including ribosome rescue, degradation of the stalled …

The signal recognition particle (SRP) enables cotranslational delivery of proteins for
translocation into the endoplasmic reticulum (ER), but its full in vivo role remains …

Golgi cisternal maturation has been visualized by fluorescence imaging of individual
cisternae in the yeast Saccharomyces cerevisiae, but those experiments did not track …

Abstract eIF2α phosphorylation-mediated translational regulation is crucial for global
translation repression by various stresses, including the unfolded protein response (UPR) …

Protein quality control (PQC) mechanisms are essential for degradation of misfolded or
dysfunctional proteins. An essential part of protein homeostasis is recognition of defective …

The yeast genome becomes unstable during stress, which often results in adaptive
aneuploidy, allowing rapid activation of protective mechanisms that restore cellular …

Parthenolide, a kind of sesquiterpene lactone, is the direct precursor for the promising anti-
glioblastoma drug ACT001. Compared with traditional parthenolide source from plant …

Upon the dysfunction or functional shortage of the endoplasmic reticulum (ER), namely, ER
stress, eukaryotic cells commonly provoke a protective gene expression program called the …