Streptococcus pneumoniae's Virulence and Host Immunity: Aging, Diagnostics, and Prevention

LRK Brooks, GI Mias - Frontiers in immunology, 2018 - frontiersin.org
Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Microbial antioxidant defense enzymes

C Staerck, A Gastebois, P Vandeputte, A Calenda… - Microbial …, 2017 - Elsevier
Free radicals are often described as chemical compounds characterized by unpaired
electrons in their outer orbital rendering them highly reactive species. In mammalians …

[HTML][HTML] How Streptococcus suis serotype 2 attempts to avoid attack by host immune defenses

X Xia, W Qin, H Zhu, X Wang, J Jiang, J Hu - Journal of Microbiology …, 2019 - Elsevier
Streptococcus suis (S. suis) type 2 (SS2) is an important zoonotic pathogen that causes
swine streptococcosis, a widespread infectious disease that occurs in pig production areas …

Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome

S Redanz, X Cheng, RA Giacaman… - Molecular Oral …, 2018 - Wiley Online Library
The majority of commensal oral streptococci are able to generate hydrogen peroxide (H2O2)
during aerobic growth, which can diffuse through the cell membrane and inhibit competing …

Overview of community‐acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease

HC Steel, R Cockeran, R Anderson… - Mediators of …, 2013 - Wiley Online Library
Community‐acquired pneumonia (CAP) remains a leading cause of morbidity and mortality
among the infectious diseases. Despite the implementation of national pneumococcal …

Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine …

SE Herring, S Mao, M Bhalla, EYI Tchalla… - Plos …, 2022 - journals.plos.org
Polymorphonuclear cells (PMNs) control Streptococcus pneumoniae (pneumococcus)
infection through various antimicrobial activities. We previously found that reactive oxygen …

A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid

HL Shearer, PE Pace, JC Paton, MB Hampton… - Journal of Biological …, 2022 - ASBMB
Hypothiocyanous acid (HOSCN) is an antimicrobial oxidant produced from hydrogen
peroxide and thiocyanate anions by heme peroxidases in secretory fluids such as in the …

Molecular architecture of Streptococcus pneumoniae surface thioredoxin‐fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of …

M Saleh, SG Bartual, MR Abdullah, I Jensch… - EMBO molecular …, 2013 - embopress.org
The respiratory pathogen Streptococcus pneumoniae has evolved efficient mechanisms to
resist oxidative stress conditions and to displace other bacteria in the nasopharynx. Here we …

Streptococcus pneumoniae two-component regulatory systems: The interplay of the pneumococcus with its environment

A Gómez-Mejia, G Gámez, S Hammerschmidt - International Journal of …, 2018 - Elsevier
Streptococcus pneumoniae is a human pathobiont possessing a diverse array of
multifunctional proteins essential for bacterial fitness and virulence. Gene expression is …

[HTML][HTML] Hypoxia and HIF-1 activation in bacterial infections

G Devraj, C Beerlage, B Brüne, VAJ Kempf - Microbes and infection, 2017 - Elsevier
For most of the living beings, oxygen is one of the essential elements required to sustain life.
Deprivation of oxygen causes tissue hypoxia and this severely affects host cell and organ …