T Kishimoto, S Kang - Annual review of Immunology, 2022 - annualreviews.org
The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …
SG Tangye, W Al-Herz, A Bousfiha, T Chatila… - Journal of clinical …, 2020 - Springer
We report the updated classification of Inborn Errors of Immunity/Primary Immunodeficiencies, compiled by the International Union of Immunological Societies Expert …
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …
Molecular, cellular, and clinical studies of human inborn errors of immunity have revolutionized our understanding of their pathogenesis, considerably broadened their …
S Kang, M Narazaki, H Metwally… - Journal of Experimental …, 2020 - rupress.org
Disclosures: Dr. Narazaki reported grants from JSPS KAKENHI and grants from Chugai Pharmaceutical Co., Ltd. during the conduct of the study; personal fees from Mitsubishi …
MD Giraldez, D Carneros, C Garbers… - Nature reviews …, 2021 - nature.com
IL-6 family cytokines are defined by the common use of the signal-transducing receptor chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …
Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in both hospital and community settings, especially with the widespread emergence of virulent …
S Zhou, Q Dai, X Huang, A Jin, Y Yang, X Gong… - Nature …, 2021 - nature.com
Skeletal deformities are typical AD-HIES manifestations, which are mainly caused by heterozygous and loss-of-function mutations in Signal transducer and activator of …
S Spencer, S Köstel Bal, W Egner… - Journal of Experimental …, 2019 - rupress.org
IL-6 excess is central to the pathogenesis of multiple inflammatory conditions and is targeted in clinical practice by immunotherapy that blocks the IL-6 receptor encoded by IL6R. We …