The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …

The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …

We report the updated classification of Inborn Errors of Immunity/Primary
Immunodeficiencies, compiled by the International Union of Immunological Societies Expert …

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Molecular, cellular, and clinical studies of human inborn errors of immunity have
revolutionized our understanding of their pathogenesis, considerably broadened their …

Disclosures: Dr. Narazaki reported grants from JSPS KAKENHI and grants from Chugai
Pharmaceutical Co., Ltd. during the conduct of the study; personal fees from Mitsubishi …

IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …

Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in
both hospital and community settings, especially with the widespread emergence of virulent …

Skeletal deformities are typical AD-HIES manifestations, which are mainly caused by
heterozygous and loss-of-function mutations in Signal transducer and activator of …

IL-6 excess is central to the pathogenesis of multiple inflammatory conditions and is targeted
in clinical practice by immunotherapy that blocks the IL-6 receptor encoded by IL6R. We …