Stroke risk factors, genetics, and prevention

AK Boehme, C Esenwa, MSV Elkind - Circulation research, 2017 - Am Heart Assoc
Stroke is a heterogeneous syndrome, and determining risk factors and treatment depends
on the specific pathogenesis of stroke. Risk factors for stroke can be categorized as …

Recommendations for the establishment of stroke systems of care: a 2019 update: a policy statement from the American Stroke Association

O Adeoye, KV Nyström, DR Yavagal, J Luciano… - Stroke, 2019 - Am Heart Assoc
In 2005, the American Stroke Association published recommendations for the establishment
of stroke systems of care and in 2013 expanded on them with a statement on interactions …

Genome-wide polygenic score to predict chronic kidney disease across ancestries

A Khan, MC Turchin, A Patki, V Srinivasasainagendra… - Nature medicine, 2022 - nature.com
Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …

Development and validation of the American Heart Association's PREVENT equations

SS Khan, K Matsushita, Y Sang, SH Ballew… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Multivariable equations are recommended by primary prevention
guidelines to assess absolute risk of cardiovascular disease (CVD). However, current …

Estimated glomerular filtration rate, albuminuria, and adverse outcomes: an individual-participant data meta-analysis

LJ Appel, M Grams, M Woodward, K Harris, H Arima… - Jama, 2023 - jamanetwork.com
Importance Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or
albuminuria) affects approximately 14% of adults in the US. Objective To evaluate …

Patterns of sedentary behavior and mortality in US middle-aged and older adults: a national cohort study

KM Diaz, VJ Howard, B Hutto… - Annals of internal …, 2017 - acpjournals.org
Background: Excessive sedentary time is ubiquitous in Western societies. Previous studies
have relied on self-reporting to evaluate the total volume of sedentary time as a prognostic …

Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome Medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …

Multinational assessment of accuracy of equations for predicting risk of kidney failure: a meta-analysis

N Tangri, ME Grams, AS Levey, J Coresh, LJ Appel… - Jama, 2016 - jamanetwork.com
Importance Identifying patients at risk of chronic kidney disease (CKD) progression may
facilitate more optimal nephrology care. Kidney failure risk equations, including such factors …

Impact of multiple social determinants of health on incident stroke

E Reshetnyak, M Ntamatungiro, LC Pinheiro… - Stroke, 2020 - Am Heart Assoc
Background and Purpose: Social determinants of health (SDOH) have been previously
associated with incident stroke. Although SDOH often cluster within individuals, few studies …

Trajectory of cognitive decline after incident stroke

DA Levine, AT Galecki, KM Langa, FW Unverzagt… - Jama, 2015 - jamanetwork.com
Importance Cognitive decline is a major cause of disability in stroke survivors. The
magnitude of survivors' cognitive changes after stroke is uncertain. Objective To measure …